High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth
نویسندگان
چکیده
We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 µm in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an imaging speed of 120,000 A-scans per second. We experimentally demonstrate the system's capability to perform phase-resolved imaging of dynamic blood flow within retina, indicating high phase stability of the SDOCT system. Finally, we show an example that uses this newly developed system to image posterior segment of human eye with a large view of view (10 × 9 mm(2)), providing detailed visualization of microstructural features from anterior retina to posterior choroid. The demonstrated system parameters and imaging performances are comparable to those that a typical 1 µm swept source OCT would deliver for retinal imaging.
منابع مشابه
Multifunctional 1050 nm Spectral Domain OCT System at 147 kHz for Posterior Eye Imaging.
We report a newly developed multifunctional 1050 nm spectral domain optical coherence tomography (SD-OCT) system working at 147 kHz A-scan rate for posterior eye imaging. It is demonstrated through in-vivo experiments that this system delivers not only superior performance of posterior eye structural imaging but also detailed visualization of microcirculation network in retina. The choroid of t...
متن کاملScalable wide-field optical coherence tomography-based angiography for in vivo imaging applications
Recent advances in optical coherence tomography (OCT)-based angiography have demonstrated a variety of biomedical applications in the diagnosis and therapeutic monitoring of diseases with vascular involvement. While promising, its imaging field of view (FOV) is however still limited (typically less than 9 mm(2)), which somehow slows down its clinical acceptance. In this paper, we report a high-...
متن کاملRetinal blood flow measurement with ultrahigh-speed swept-source / Fourier domain optical coherence tomography
Doppler OCT is a functional extension of OCT that provides information on flow in biological tissues. We present a novel approach for total retinal blood flow assessment using ultrahigh speed Doppler OCT. A swept source / Fourier domain OCT system at 1050 nm was used for 3D imaging of the human retina. The high axial scan rate of 200 kHz allowed measuring the high flow velocities in the central...
متن کاملHigh speed spectral domain optical coherence tomography for retinal imaging at 500,000 A‑lines per second
We present a new development of ultrahigh speed spectral domain optical coherence tomography (SDOCT) for human retinal imaging at 850 nm central wavelength by employing two high-speed line scan CMOS cameras, each running at 250 kHz. Through precisely controlling the recording and reading time periods of the two cameras, the SDOCT system realizes an imaging speed at 500,000 A-lines per second, w...
متن کاملUltrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second.
We demonstrate ultrahigh speed swept source/Fourier domain ophthalmic OCT imaging using a short cavity swept laser at 100,000 - 400,000 axial scan rates. Several design configurations illustrate tradeoffs in imaging speed, sensitivity, axial resolution, and imaging depth. Variable rate A/D optical clocking is used to acquire linear-in-k OCT fringe data at 100 kHz axial scan rate with 5.3 um axi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2013